Immature B cell differentiation

Across TCGA cell cohorts, RNA activity of the Immature B cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERP29, UBC, and DENND2B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Immature B cell differentiation activity versus ERP29 in STOMACH (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ERP29 →	+0.805	+1.489	.003	.003	3	4
PANCREAS	UBC →	+0.693	+1.255	.002	.002	3	3
BLOOD_Myeloma	DENND2B →	+2.242	+1.245	.001	.002	3	3
BLOOD_Myeloma	FUCA1 →	+1.023	+1.228	.005	.002	3	3
BONE	POLR2I →	-0.429	-0.520	.005	<.001	3	3
BONE	ZNF330 →	+0.745	+0.537	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002327 vs ERP29 — STOMACH

Explore this scatter interactively →