Natural killer cell activation involved in immune response

Across TCGA patient cohorts, RNA activity of the Natural killer cell activation involved in immune response pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GBP1, NKG7, and STX11, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Natural killer cell activation involved in immune response activity versus GBP1 in COAD (Pearson r = -0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GBP1 →	+1.414	+0.225	<.001	<.001	3	9
COAD	NKG7 →	+1.401	+0.274	<.001	<.001	3	9
UCEC	STX11 →	+0.737	+0.302	<.001	<.001	3	9
COAD	CASP1 →	+0.855	+0.144	.002	.006	3	9
UCEC	GBP5 →	+1.533	+0.307	<.001	<.001	3	9
UCEC	FCER1G →	+1.298	+0.297	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002323 vs GBP1 — COAD

Explore this scatter interactively →