Natural killer cell activation involved in immune response

Across TCGA cell cohorts, RNA activity of the Natural killer cell activation involved in immune response pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RHOA, HYAL2, and CEP250, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RHOA grouped by Natural killer cell activation involved in immune response-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RHOA →	+0.679	+0.753	.004	.008	3	4
PANCREAS	HYAL2 →	+0.771	+1.128	.008	.004	3	4
LUNG_SCLC	CEP250 →	+1.141	+1.157	.008	.003	3	4
LUNG_SCLC	SYNRG →	+0.791	+0.914	.007	.007	3	4
PANCREAS	CFL1 →	+0.766	+1.055	.002	.009	3	4
URINARY_TRACT	ARHGEF4 →	-2.245	-1.569	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RHOA by Natural killer cell activation involved in immune response activity — OVARY

Explore this box plot interactively →