Myeloid progenitor cell differentiation

pathway activity — cross-omics
GO:0002318Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Myeloid progenitor cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC89, RP1, and TEKT3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADCCDC89 →+0.281+0.677.004.00433
LSCCRP1 →+0.791+0.620<.001.00533
LSCCTEKT3 →+0.264+0.714<.001<.00133
LSCCRGS22 →+0.577+0.842<.001<.00133
LSCCARMC4 →+0.968+0.760<.001.00233
LSCCDNAH12 →+0.894+0.733.004.00333
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

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