Marginal zone B cell differentiation

Across TCGA patient cohorts, RNA activity of the Marginal zone B cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the PAAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSF2RB, TLR8, and CD33, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Marginal zone B cell differentiation activity versus CSF2RB in PAAD (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PAAD	CSF2RB →	+1.704	+0.101	<.001	<.001	3	34
LAML	TLR8 →	+2.865	+0.159	<.001	<.001	3	34
SARC	CD33 →	+1.210	+0.068	<.001	<.001	3	34
SARC	IL10RA →	+1.838	+0.074	<.001	<.001	3	34
SCLC	NCKAP1L →	+2.666	+0.202	<.001	<.001	3	34
CHOL	WDFY4 →	+1.612	+0.091	<.001	.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002315 vs CSF2RB — PAAD

Explore this scatter interactively →