Marginal zone B cell differentiation

Across TCGA cell cohorts, RNA activity of the Marginal zone B cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIMM9, CREM, and PTP4A2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Marginal zone B cell differentiation activity versus TIMM9 in CNS (Pearson r = 0.89).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TIMM9 →	+0.706	+1.953	.006	<.001	3	4
BLOOD_Leukemia	CREM →	-1.279	-1.737	.008	.007	3	3
BLOOD_Leukemia	PTP4A2 →	-2.136	-1.829	<.001	<.001	3	3
LUNG_NSCLC_LUAD	RAPGEF1 →	-1.212	-2.051	.001	<.001	3	3
PANCREAS	PIN4 →	-0.525	-0.478	.001	.009	2	3
PANCREAS	TNS3 →	-1.775	-0.478	<.001	.009	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002315 vs TIMM9 — CNS

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