Marginal zone B cell differentiation

Across TCGA cell cohorts, RNA activity of the Marginal zone B cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CDH17, DARS2, and BLVRB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Marginal zone B cell differentiation activity versus CDH17 in BREAST (Pearson r = 0.97).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CDH17 →	+2.843	+1.977	.008	<.001	3	5
BLOOD_Lymphoma	DARS2 →	+1.245	+1.503	.007	.007	3	4
BREAST	BLVRB →	+3.253	+1.977	<.001	<.001	3	3
LUNG_NSCLC_LUAD	MRPL44 →	+0.526	+1.623	.005	.005	3	3
LUNG_NSCLC_LUAD	SH3GL1 →	-1.446	-1.572	.002	.005	3	3
BLOOD_Lymphoma	IGBP1 →	-0.651	-1.070	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002315 vs CDH17 — BREAST

Explore this scatter interactively →