Germinal center B cell differentiation

Across TCGA patient cohorts, RNA activity of the Germinal center B cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POU2F2, ARL3, and MAPRE2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Germinal center B cell differentiation activity versus POU2F2 in CCRCC (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	POU2F2 →	+0.372	+0.762	.007	.001	3	4
UCEC	ARL3 →	-0.398	-0.783	.006	<.001	3	4
COAD	MAPRE2 →	-0.516	-0.271	.004	.009	3	3
OV	ACER3 →	-0.551	-0.374	.005	.007	3	3
OV	ICMT →	-0.330	-0.298	.003	.001	3	3
OV	TTLL7 →	-0.772	-0.323	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002314 vs POU2F2 — CCRCC

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