Germinal center B cell differentiation

Across TCGA cell cohorts, RNA activity of the Germinal center B cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIGD4, PRPF40B, and PPP1R3G, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TIGD4 grouped by Germinal center B cell differentiation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TIGD4 →	-0.473	-1.456	.004	.001	3	4
SOFT_TISSUE	PRPF40B →	-0.877	-1.409	.003	<.001	3	4
BLOOD_Leukemia	PPP1R3G →	+1.130	+1.302	.003	<.001	3	4
SOFT_TISSUE	B3GNT5 →	+2.535	+1.582	<.001	<.001	3	4
SOFT_TISSUE	CIPC →	-0.738	-1.359	<.001	<.001	3	4
CNS	S100A3 →	+1.706	+1.007	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TIGD4 by Germinal center B cell differentiation activity — SOFT_TISSUE

Explore this box plot interactively →