Germinal center B cell differentiation

Across TCGA cell cohorts, RNA activity of the Germinal center B cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHF14, BCAM, and TNNC1, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Germinal center B cell differentiation activity versus PHF14 in BONE (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PHF14 →	+1.261	+0.471	<.001	<.001	3	13
STOMACH	BCAM →	-2.469	-0.298	<.001	.008	3	9
STOMACH	TNNC1 →	-3.486	-0.277	.001	<.001	3	8
KIDNEY	IL6 →	+2.801	+0.416	.001	.002	3	7
BREAST	TLR3 →	-1.179	-0.216	<.001	.003	2	8
BLOOD_Lymphoma	SLC22A18 →	-1.208	-0.166	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002314 vs PHF14 — BONE

Explore this scatter interactively →