Mature B cell differentiation involved in immune response

Across TCGA patient cohorts, RNA activity of the Mature B cell differentiation involved in immune response pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RASAL3, BIN2, and CD2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mature B cell differentiation involved in immune response activity versus RASAL3 in BRCA (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RASAL3 →	+0.961	+0.886	<.001	<.001	3	9
BRCA	BIN2 →	+0.888	+0.937	<.001	<.001	3	9
BRCA	CD2 →	+1.474	+0.717	<.001	.002	3	9
OV	FAM78A →	+0.696	+0.869	.003	.005	3	9
BRCA	CD6 →	+1.096	+0.769	<.001	<.001	3	9
BRCA	SNX20 →	+0.972	+0.889	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002313 vs RASAL3 — BRCA

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