Mature B cell differentiation involved in immune response

Across TCGA cell cohorts, RNA activity of the Mature B cell differentiation involved in immune response pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYCBP, CEP57, and PPP3CB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MYCBP grouped by Mature B cell differentiation involved in immune response-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MYCBP →	-0.444	-0.632	.005	.001	3	5
UPPER_AERODIGESTIVE_TRACT	CEP57 →	-1.506	-1.167	.001	.007	3	4
LIVER	PPP3CB →	+1.071	+1.451	<.001	<.001	3	4
LIVER	RBM3 →	+0.998	+1.384	.002	.004	3	4
UPPER_AERODIGESTIVE_TRACT	WNT3 →	-1.047	-1.320	.001	.007	3	3
UPPER_AERODIGESTIVE_TRACT	TTC19 →	-1.104	-1.234	.007	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MYCBP by Mature B cell differentiation involved in immune response activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →