B cell activation involved in immune response

Across TCGA cell cohorts, RNA activity of the B cell activation involved in immune response pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ST3GAL1, ARHGDIB, and PDCD4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, B cell activation involved in immune response activity versus ST3GAL1 in OVARY (Pearson r = -0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ST3GAL1 →	-1.690	-0.120	.001	.009	3	5
BLOOD_Lymphoma	ARHGDIB →	-3.053	-0.182	.008	.002	3	5
LARGE_INTESTINE	PDCD4 →	+0.946	+0.196	.004	.004	3	5
LUNG_NSCLC_LUSC	ASIC1 →	+0.865	+0.284	.004	.009	3	4
LIVER	NFATC1 →	+1.935	+0.218	<.001	.009	3	4
LIVER	IL6ST →	-1.340	-0.215	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002312 vs ST3GAL1 — OVARY

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