T cell proliferation involved in immune response

Across TCGA patient cohorts, RNA activity of the T cell proliferation involved in immune response pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ERO1A_S106, ARRB2, and PLAUR, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell proliferation involved in immune response activity versus ERO1A_S106 in GBM (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ERO1A_S106 →	+1.058	+0.071	<.001	.007	3	8
LSCC	ARRB2 →	+0.311	+0.099	<.001	<.001	3	8
CCRCC	PLAUR →	+0.722	+0.082	.007	<.001	3	8
LSCC	PFN1 →	+0.298	+0.102	<.001	<.001	3	8
GBM	SKAP2 →	+0.730	+0.135	<.001	<.001	3	7
LSCC	THEMIS2_T593 →	+0.689	+0.116	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002309 vs ERO1A_S106 — GBM

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