T cell proliferation involved in immune response

Across TCGA patient cohorts, RNA activity of the T cell proliferation involved in immune response pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TP53, SCCPDH, and PLLP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell proliferation involved in immune response activity versus TP53 in OV (Pearson r = -0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TP53 →	+1.296	+0.462	<.001	<.001	3	4
COAD	SCCPDH →	-0.337	-0.236	.005	.005	3	4
GBM	PLLP →	-0.582	-0.234	.002	<.001	3	4
BRCA	THRA →	-0.712	-0.238	.002	.001	2	4
BRCA	FAM110B →	-0.992	-0.316	.002	<.001	3	3
BRCA	PDGFD →	-0.608	-0.243	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002309 vs TP53 — OV

Explore this scatter interactively →