T-helper cell lineage commitment

Across TCGA cell cohorts, RNA activity of the T-helper cell lineage commitment pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPC2, HSPA14, and ALG11, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NPC2 grouped by T-helper cell lineage commitment-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	NPC2 →	-0.216	-0.889	.005	.008	3	3
BONE	HSPA14 →	+0.154	+0.384	.003	.006	2	3
LUNG_SCLC	ALG11 →	-0.232	-1.165	<.001	.008	3	2
BREAST	KCTD9 →	-0.123	-0.784	<.001	.005	3	2
BREAST	MCL1 →	+0.349	+1.185	<.001	.001	3	2
CNS	POU2F3 →	-0.199	-1.282	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NPC2 by T-helper cell lineage commitment activity — CNS

Explore this box plot interactively →