T-helper cell lineage commitment

Across TCGA cell cohorts, RNA activity of the T-helper cell lineage commitment pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHORDC1, PLEKHH3, and MIB2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T-helper cell lineage commitment activity versus CHORDC1 in BONE (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CHORDC1 →	-1.174	-0.480	.004	.003	3	3
BLOOD_Leukemia	PLEKHH3 →	+1.380	+0.164	<.001	.003	3	3
BLOOD_Myeloma	MIB2 →	+1.177	+1.198	.005	.003	3	3
PANCREAS	ROBO1 →	-2.158	-0.925	.006	.004	3	3
CNS	AXL →	+1.472	+0.830	<.001	.001	3	3
CNS	TUSC1 →	+1.616	+0.717	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002295 vs CHORDC1 — BONE

Explore this scatter interactively →