T cell differentiation involved in immune response

Across TCGA patient cohorts, RNA activity of the T cell differentiation involved in immune response pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, TBXAS1, and TNFAIP8L2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell differentiation involved in immune response activity versus RCSD1 in HNSC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RCSD1 →	+0.621	+0.045	<.001	<.001	3	10
GBM	TBXAS1 →	+0.628	+0.086	<.001	<.001	3	10
GBM	TNFAIP8L2 →	+0.684	+0.055	<.001	<.001	3	10
COAD	TRAF1 →	+0.608	+0.037	.002	.004	3	10
BRCA	ZAP70 →	+0.663	+0.031	<.001	<.001	3	10
OV	CCDC88B_S597 →	+0.930	+0.039	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002292 vs RCSD1 — HNSC

Explore this scatter interactively →