T cell differentiation involved in immune response

Across TCGA patient cohorts, RNA activity of the T cell differentiation involved in immune response pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CIITA, TNIP3, and SIRPB1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell differentiation involved in immune response activity versus CIITA in GBM (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CIITA →	+0.656	+0.238	.002	.008	3	7
CCRCC	TNIP3 →	+1.217	+0.512	<.001	<.001	3	6
CCRCC	SIRPB1 →	+0.678	+0.474	<.001	<.001	3	6
LSCC	CSF3R →	+1.084	+0.724	<.001	<.001	3	6
GBM	LILRB2 →	+0.722	+0.229	<.001	.001	3	6
LSCC	TRGV8 →	+0.531	+0.547	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002292 vs CIITA — GBM

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