T cell differentiation involved in immune response

Across TCGA cell cohorts, RNA activity of the T cell differentiation involved in immune response pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP29, CDT1, and UQCRC1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell differentiation involved in immune response activity versus ARHGAP29 in LUNG_NSCLC_LUAD (Pearson r = -0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ARHGAP29 →	-1.226	-0.237	.002	.002	3	7
OVARY	CDT1 →	+1.071	+0.430	<.001	.001	3	6
SKIN	UQCRC1 →	+0.905	+0.494	.008	.006	3	6
LIVER	GRK2 →	+1.424	+0.386	.007	.002	3	6
PANCREAS	METTL21A →	+0.779	+0.383	.003	.003	3	5
BLOOD_Leukemia	POLR3K →	+0.567	+0.171	.002	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002292 vs ARHGAP29 — LUNG_NSCLC_LUAD

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