T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

Across TCGA patient cohorts, RNA activity of the T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL2RB, GZMH, and HCK, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell activity versus IL2RB in SCLC (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	IL2RB →	+2.446	+0.388	<.001	<.001	3	34
SKCM	GZMH →	+2.453	+0.151	<.001	<.001	3	34
SARC	HCK →	+2.402	+0.182	<.001	<.001	3	34
SCLC	ABI3 →	+2.584	+0.395	<.001	<.001	3	34
SKCM	CRTAM →	+1.690	+0.162	<.001	<.001	3	34
DLBC	IFNG →	+2.125	+0.129	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002291 vs IL2RB — SCLC

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