T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

Across TCGA patient cohorts, RNA activity of the T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, RCSD1_S351, and RENBP, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell activity versus RCSD1 in GBM (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RCSD1 →	+0.696	+0.178	<.001	<.001	3	10
OV	RCSD1_S351 →	+0.708	+0.088	.002	<.001	3	10
UCEC	RENBP →	+0.521	+0.114	<.001	<.001	3	10
GBM	RIN3 →	+0.475	+0.144	<.001	<.001	3	10
HNSC	SAMHD1 →	+0.642	+0.134	<.001	<.001	3	10
GBM	SAMSN1_S107 →	+0.920	+0.187	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002291 vs RCSD1 — GBM

Explore this scatter interactively →