T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

Across TCGA patient cohorts, RNA activity of the T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BIN2, SP140, and FYB1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell activity versus BIN2 in HNSC (Pearson r = 0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	BIN2 →	+0.932	+0.265	<.001	<.001	3	10
UCEC	SP140 →	+0.888	+0.230	.001	<.001	3	10
GBM	FYB1 →	+1.198	+0.248	<.001	<.001	3	10
OV	TRAF3IP3 →	+0.743	+0.268	<.001	.001	3	10
HNSC	TNFSF13B →	+0.793	+0.195	<.001	<.001	3	10
GBM	BTK →	+0.922	+0.266	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002291 vs BIN2 — HNSC

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