T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

Across TCGA cell cohorts, RNA activity of the T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOL6, CNRIP1, and ATP5PO, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NOL6 grouped by T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	NOL6 →	-0.420	-0.756	.007	<.001	3	4
BLOOD_Myeloma	CNRIP1 →	-0.048	-2.192	.003	<.001	3	4
LARGE_INTESTINE	ATP5PO →	+0.440	+0.855	.004	.006	2	5
OESOPHAGUS	AIM2 →	-1.654	-1.840	.006	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	PRDM8 →	-1.533	-1.633	.003	<.001	3	3
CNS	TRIM2 →	+0.744	+0.724	.005	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NOL6 by T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →