T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

Across TCGA cell cohorts, RNA activity of the T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYEF2, RNF180, and SMIM19, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell activity versus MYEF2 in PANCREAS (Pearson r = -0.94).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MYEF2 →	-4.873	-1.705	.007	<.001	3	2
PANCREAS	RNF180 →	-0.785	-1.835	<.001	.001	3	2
PANCREAS	SMIM19 →	+1.456	+1.705	.003	<.001	3	2
LARGE_INTESTINE	THEMIS2 →	-1.928	-1.749	.003	<.001	3	2
LARGE_INTESTINE	KHDRBS3 →	-3.170	-1.749	.005	<.001	3	2
BREAST	SEMA5A →	-1.202	-1.422	.003	.001	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002291 vs MYEF2 — PANCREAS

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