Microglial cell activation involved in immune response

Across TCGA patient cohorts, RNA activity of the Microglial cell activation involved in immune response pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD300E, CCRL2, and VAV1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microglial cell activation involved in immune response activity versus CD300E in GBM (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CD300E →	+0.816	+0.641	.001	<.001	3	5
HNSC	CCRL2 →	+0.752	+0.151	<.001	<.001	3	4
HNSC	VAV1 →	+0.588	+0.097	.003	<.001	3	4
CCRCC	KCNAB2 →	+0.463	+0.288	<.001	.005	3	4
HNSC	FYB1 →	+0.931	+0.132	<.001	<.001	3	4
HNSC	SIRPB1 →	+0.528	+0.165	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002282 vs CD300E — GBM

Explore this scatter interactively →