Microglial cell activation involved in immune response

Across TCGA cell cohorts, RNA activity of the Microglial cell activation involved in immune response pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FADS1, CCDC191, and TRAPPC6A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FADS1 grouped by Microglial cell activation involved in immune response-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	FADS1 →	+1.254	+1.349	<.001	<.001	3	4
CNS	CCDC191 →	+0.721	+0.923	.001	.002	3	4
LIVER	TRAPPC6A →	+1.764	+1.209	<.001	<.001	3	4
SKIN	OBSL1 →	+1.232	+0.960	.001	.002	3	4
BONE	SEMA4D →	+1.320	+1.373	.003	.001	3	4
LUNG_NSCLC_LUSC	EMC7 →	+0.749	+1.445	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FADS1 by Microglial cell activation involved in immune response activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →