Microglial cell activation involved in immune response

Across TCGA cell cohorts, RNA activity of the Microglial cell activation involved in immune response pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VPS29, SNRPB2, and ATG3, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microglial cell activation involved in immune response activity versus VPS29 in BLOOD_Leukemia (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	VPS29 →	+0.865	+1.853	.009	<.001	2	1
BLOOD_Leukemia	SNRPB2 →	+1.055	+1.667	.006	.006	2	1
BLOOD_Leukemia	ATG3 →	+1.245	+1.853	.005	<.001	2	1
BLOOD_Leukemia	ASAP1 →	+1.429	+1.661	.009	.006	2	1
BLOOD_Leukemia	PTDSS2 →	-0.945	-1.661	.004	.006	2	1
BLOOD_Leukemia	AP3B2 →	+3.630	+1.402	.001	.001	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002282 vs VPS29 — BLOOD_Leukemia

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