Myeloid cell activation involved in immune response

Across TCGA cell cohorts, RNA activity of the Myeloid cell activation involved in immune response pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NAA10, FAM107B, and PITX1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NAA10 grouped by Myeloid cell activation involved in immune response-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	NAA10 →	-0.550	-1.236	<.001	<.001	3	3
KIDNEY	FAM107B →	+1.624	+1.060	<.001	<.001	3	3
KIDNEY	PITX1 →	-1.789	-0.975	.002	.003	3	3
OVARY	ANKRD18B →	+1.340	+0.993	.003	.003	3	3
KIDNEY	IQCH →	+0.538	+1.165	.001	.002	3	2
KIDNEY	NAMPT →	-1.241	-0.991	.003	.004	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NAA10 by Myeloid cell activation involved in immune response activity — KIDNEY

Explore this box plot interactively →