Myeloid cell activation involved in immune response

Across TCGA cell cohorts, RNA activity of the Myeloid cell activation involved in immune response pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EVI5L, SPIRE1, and GNA11, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myeloid cell activation involved in immune response activity versus EVI5L in LUNG_SCLC (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	EVI5L →	+0.814	+0.147	.008	.007	3	6
PANCREAS	SPIRE1 →	+1.085	+0.167	<.001	.003	3	4
PANCREAS	GNA11 →	+0.858	+0.187	<.001	.006	3	4
URINARY_TRACT	LAMB2 →	+1.532	+1.101	.001	.005	3	4
LIVER	CDC37L1 →	+0.764	+0.436	.008	<.001	3	3
LIVER	SRF →	+1.022	+0.328	.002	.009	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002275 vs EVI5L — LUNG_SCLC

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