Leukocyte activation involved in inflammatory response

Across TCGA patient cohorts, RNA activity of the Leukocyte activation involved in inflammatory response pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RIN3, STAB1, and WAS, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leukocyte activation involved in inflammatory response activity versus RIN3 in COAD (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RIN3 →	+0.591	+0.054	<.001	<.001	3	10
GBM	STAB1 →	+0.611	+0.075	<.001	<.001	3	10
GBM	WAS →	+0.697	+0.095	<.001	<.001	3	10
UCEC	CARD16 →	+0.642	+0.054	<.001	.002	3	10
UCEC	ADPRH →	+0.368	+0.048	<.001	<.001	3	10
UCEC	GIMAP7 →	+0.596	+0.076	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002269 vs RIN3 — COAD

Explore this scatter interactively →