Leukocyte activation involved in inflammatory response

Across TCGA patient cohorts, RNA activity of the Leukocyte activation involved in inflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFRSF8, BCL2A1, and LILRB3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leukocyte activation involved in inflammatory response activity versus TNFRSF8 in GBM (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TNFRSF8 →	+0.533	+0.165	<.001	<.001	3	10
GBM	BCL2A1 →	+1.392	+0.217	<.001	<.001	3	10
GBM	LILRB3 →	+1.093	+0.206	<.001	<.001	3	10
GBM	LCP2 →	+0.953	+0.170	<.001	<.001	3	10
GBM	SPI1 →	+0.916	+0.178	<.001	<.001	3	10
GBM	FGR →	+1.055	+0.225	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002269 vs TNFRSF8 — GBM

Explore this scatter interactively →