Leukocyte activation involved in inflammatory response

Across TCGA cell cohorts, RNA activity of the Leukocyte activation involved in inflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LZTS3, LUC7L3, and FAM193B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LZTS3 grouped by Leukocyte activation involved in inflammatory response-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	LZTS3 →	+0.946	+0.371	.009	.009	3	4
SKIN	LUC7L3 →	+0.492	+1.533	.004	<.001	3	4
SKIN	FAM193B →	+0.630	+0.969	.003	.008	3	4
URINARY_TRACT	F3 →	-1.680	-1.658	<.001	<.001	3	3
URINARY_TRACT	FAM8A1 →	+0.878	+1.807	<.001	<.001	3	3
URINARY_TRACT	GPX1 →	-1.382	-1.846	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LZTS3 by Leukocyte activation involved in inflammatory response activity — BONE

Explore this box plot interactively →