Leukocyte activation involved in inflammatory response

Across TCGA cell cohorts, RNA activity of the Leukocyte activation involved in inflammatory response pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PON1, RIT2, and PRR5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PON1 grouped by Leukocyte activation involved in inflammatory response-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PON1 →	+0.105	+0.160	.002	<.001	3	5
PANCREAS	RIT2 →	-0.241	-0.243	.004	<.001	3	4
PANCREAS	PRR5 →	+0.099	+0.170	.004	.004	3	4
BLOOD_Myeloma	LEF1 →	-0.283	-0.129	.005	.003	3	4
LARGE_INTESTINE	EPRS1 →	-0.234	-0.225	<.001	<.001	3	4
OESOPHAGUS	ATPAF1 →	+0.122	+0.177	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PON1 by Leukocyte activation involved in inflammatory response activity — OESOPHAGUS

Explore this box plot interactively →