Leukocyte activation involved in inflammatory response

Across TCGA cell cohorts, RNA activity of the Leukocyte activation involved in inflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSNK1A1, HIBCH, and FLOT2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leukocyte activation involved in inflammatory response activity versus CSNK1A1 in KIDNEY (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	CSNK1A1 →	+0.804	+1.552	.001	.004	3	5
CNS	HIBCH →	+0.545	+0.930	.001	.005	3	5
LUNG_NSCLC_LUAD	FLOT2 →	-0.641	-0.862	<.001	.001	3	4
BLOOD_Leukemia	UBE2W →	+0.916	+1.357	<.001	<.001	3	4
BLOOD_Leukemia	PRAM1 →	+3.277	+1.024	<.001	<.001	3	4
BLOOD_Leukemia	C1orf162 →	+2.047	+1.107	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002269 vs CSNK1A1 — KIDNEY

Explore this scatter interactively →