Myeloid cell homeostasis

Across TCGA patient cohorts, RNA activity of the Myeloid cell homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STAB1, ANKRD44, and GEM_S23, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myeloid cell homeostasis activity versus STAB1 in GBM (Pearson r = 0.68).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	STAB1 →	+0.529	+0.037	<.001	<.001	3	9
OV	ANKRD44 →	+0.452	+0.031	<.001	.001	3	9
LSCC	GEM_S23 →	+0.858	+0.045	.001	<.001	3	9
LSCC	PPM1F →	+0.205	+0.032	.009	.001	3	9
OV	SEPTIN4 →	+0.704	+0.032	<.001	.006	3	8
GBM	TBC1D2B →	+0.363	+0.036	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002262 vs STAB1 — GBM

Explore this scatter interactively →