Myeloid cell homeostasis

Across TCGA patient cohorts, RNA activity of the Myeloid cell homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPL46, DHRS9, and VARS2, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myeloid cell homeostasis activity versus MRPL46 in BRCA (Pearson r = -0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MRPL46 →	+0.584	+0.306	<.001	<.001	3	2
COAD	DHRS9 →	-1.312	-0.173	.001	.005	3	2
OV	VARS2 →	+0.108	+0.252	<.001	<.001	3	2
OV	SNORA2A →	+0.991	+0.202	<.001	.008	3	2
BRCA	GRB10 →	-1.093	-0.274	.002	.001	3	1
BRCA	FGF8 →	+0.121	+0.213	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002262 vs MRPL46 — BRCA

Explore this scatter interactively →