Myeloid cell homeostasis

Across TCGA cell cohorts, RNA activity of the Myeloid cell homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GALK2, ANXA1, and SERPING1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myeloid cell homeostasis activity versus GALK2 in BREAST (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GALK2 →	+0.757	+0.215	.001	<.001	3	6
STOMACH	ANXA1 →	+3.814	+0.219	.008	.004	2	5
STOMACH	SERPING1 →	-2.772	-0.164	.006	.009	3	4
STOMACH	MEIOC →	-0.890	-0.164	.003	.008	3	4
STOMACH	MVB12B →	-1.288	-0.202	.004	<.001	2	5
STOMACH	OGDHL →	-2.211	-0.217	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002262 vs GALK2 — BREAST

Explore this scatter interactively →