Lymphocyte homeostasis

Across TCGA patient cohorts, RNA activity of the Lymphocyte homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP25, CD86, and LAPTM5, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lymphocyte homeostasis activity versus ARHGAP25 in HNSC (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ARHGAP25 →	+0.618	+0.692	.001	<.001	3	7
HNSC	CD86 →	+0.673	+0.696	.005	<.001	2	8
COAD	LAPTM5 →	+0.890	+0.794	<.001	<.001	3	7
HNSC	CYBB →	+1.200	+0.822	<.001	<.001	3	7
HNSC	KLHL6 →	+0.972	+1.065	<.001	<.001	3	7
HNSC	HCLS1 →	+1.079	+0.763	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002260 vs ARHGAP25 — HNSC

Explore this scatter interactively →