Lymphocyte homeostasis

Across TCGA cell cohorts, RNA activity of the Lymphocyte homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCBP1, BCL7A, and TARDBP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lymphocyte homeostasis activity versus PCBP1 in PANCREAS (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PCBP1 →	+0.531	+0.336	<.001	.002	3	6
BLOOD_Myeloma	BCL7A →	+2.248	+0.292	.003	.007	3	5
PANCREAS	TARDBP →	+0.527	+0.361	.002	.007	3	5
LIVER	MPHOSPH10 →	+0.838	+0.351	.003	<.001	3	5
PANCREAS	TFAP4 →	+0.957	+0.307	<.001	.007	3	5
PANCREAS	XYLB →	+1.054	+0.299	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002260 vs PCBP1 — PANCREAS

Explore this scatter interactively →