Connective tissue replacement involved in inflammatory response wound healing

Across TCGA patient cohorts, RNA activity of the Connective tissue replacement involved in inflammatory response wound healing pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BATF3, ABLIM3, and RASAL3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Connective tissue replacement involved in inflammatory response wound healing activity versus BATF3 in UCEC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BATF3 →	+0.529	+0.754	.003	<.001	3	4
UCEC	ABLIM3 →	+0.575	+0.887	.001	<.001	3	4
OV	RASAL3 →	+0.715	+0.224	<.001	<.001	3	4
OV	C1orf162 →	+0.694	+0.211	<.001	.001	3	4
OV	GBGT1 →	+0.549	+0.182	<.001	.006	3	4
GBM	SIRPB2 →	+0.767	+0.570	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002248 vs BATF3 — UCEC

Explore this scatter interactively →