Connective tissue replacement involved in inflammatory response wound healing

Across TCGA cell cohorts, RNA activity of the Connective tissue replacement involved in inflammatory response wound healing pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are P2RY11, ZGLP1, and IRF5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, P2RY11 grouped by Connective tissue replacement involved in inflammatory response wound healing-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	P2RY11 →	+1.180	+0.962	<.001	.001	3	6
CNS	ZGLP1 →	+0.529	+0.729	.004	.009	3	4
OVARY	IRF5 →	+1.691	+1.250	.004	.001	3	4
LARGE_INTESTINE	H4C8 →	+0.987	+0.946	.004	.006	2	4
LUNG_SCLC	SLC22A23 →	-1.809	-1.133	.001	.004	3	3
LUNG_SCLC	MRPL10 →	-0.605	-1.050	.006	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

P2RY11 by Connective tissue replacement involved in inflammatory response wound healing activity — PANCREAS

Explore this box plot interactively →