Wound healing involved in inflammatory response

Across TCGA cell cohorts, RNA activity of the Wound healing involved in inflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPAP1, ATP6V0A1, and APBA3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPAP1 grouped by Wound healing involved in inflammatory response-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RPAP1 →	+0.814	+1.302	<.001	<.001	3	5
PANCREAS	ATP6V0A1 →	+0.868	+1.434	<.001	<.001	3	4
STOMACH	APBA3 →	+0.656	+1.229	<.001	.001	3	4
BLOOD_Myeloma	C12orf4 →	+1.123	+1.148	.001	.007	3	4
SOFT_TISSUE	GATD3A →	-1.704	-1.334	.009	.001	3	3
UPPER_AERODIGESTIVE_TRACT	GNAO1 →	+1.799	+1.242	.007	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPAP1 by Wound healing involved in inflammatory response activity — PANCREAS

Explore this box plot interactively →