Leukocyte chemotaxis involved in inflammatory response

Across TCGA patient cohorts, RNA activity of the Leukocyte chemotaxis involved in inflammatory response pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARHGEF6, DOCK10, and HCLS1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leukocyte chemotaxis involved in inflammatory response activity versus ARHGEF6 in COAD (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ARHGEF6 →	+0.419	+0.076	<.001	<.001	3	8
LSCC	DOCK10 →	+0.394	+0.083	<.001	<.001	3	7
BRCA	HCLS1 →	+0.474	+0.067	<.001	<.001	3	7
LSCC	ANKRD44 →	+0.371	+0.080	<.001	<.001	3	7
BRCA	ARHGAP30_S709 →	+0.729	+0.061	<.001	<.001	3	7
LSCC	ARHGEF6_S225 →	+0.575	+0.073	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002232 vs ARHGEF6 — COAD

Explore this scatter interactively →