Leukocyte chemotaxis involved in inflammatory response

Across TCGA cell cohorts, RNA activity of the Leukocyte chemotaxis involved in inflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are S100A2, PIM1, and LRRFIP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, S100A2 grouped by Leukocyte chemotaxis involved in inflammatory response-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	S100A2 →	-2.478	-0.684	<.001	.003	3	5
BLOOD_Lymphoma	PIM1 →	-3.887	-1.712	.002	<.001	3	4
BONE	LRRFIP2 →	-1.453	-1.269	<.001	.004	3	4
CNS	DET1 →	+0.379	+0.837	.004	.004	2	5
UPPER_AERODIGESTIVE_TRACT	TMEM8B →	+1.593	+1.073	<.001	.003	3	4
KIDNEY	LRTM2 →	+0.042	+1.052	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

S100A2 by Leukocyte chemotaxis involved in inflammatory response activity — BREAST

Explore this box plot interactively →