Positive regulation of defense response to virus by host

Across TCGA cell cohorts, RNA activity of the Positive regulation of defense response to virus by host pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBL5, CCDC96, and TASOR2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UBL5 grouped by Positive regulation of defense response to virus by host-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	UBL5 →	-0.408	-0.545	.004	<.001	3	4
LUNG_SCLC	CCDC96 →	-0.827	-0.235	.008	.007	2	5
CNS	TASOR2 →	+0.614	+0.831	<.001	.002	3	3
CNS	SPRYD3 →	-0.703	-0.757	.003	<.001	3	3
SOFT_TISSUE	GALK2 →	-0.959	-1.361	.006	.004	3	3
SOFT_TISSUE	TPRG1L →	-0.674	-1.054	.006	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UBL5 by Positive regulation of defense response to virus by host activity — SKIN

Explore this box plot interactively →