Natural killer cell mediated immunity

Across TCGA patient cohorts, RNA activity of the Natural killer cell mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-F, NKG7, and IL2RG, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Natural killer cell mediated immunity activity versus HLA-F in HNSC (Pearson r = -0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	HLA-F →	+0.858	+0.178	<.001	.001	3	8
CCRCC	NKG7 →	+1.003	+0.211	<.001	<.001	3	7
HNSC	IL2RG →	+1.212	+0.289	<.001	<.001	3	7
LSCC	PRMT3 →	-0.545	-0.238	<.001	<.001	3	7
LSCC	CD72 →	+0.642	+0.188	<.001	<.001	3	7
CCRCC	GBP5 →	+1.690	+0.291	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002228 vs HLA-F — HNSC

Explore this scatter interactively →