Innate immune response in mucosa

Across TCGA patient cohorts, RNA activity of the Innate immune response in mucosa pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FFAR2, CXCL8, and BCL2A1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Innate immune response in mucosa activity versus FFAR2 in LSCC (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FFAR2 →	+0.755	+0.175	.003	<.001	3	8
UCEC	CXCL8 →	+2.293	+0.351	<.001	<.001	3	8
UCEC	BCL2A1 →	+1.437	+0.267	<.001	.001	3	7
LSCC	FCGR3B →	+1.251	+0.149	<.001	<.001	3	7
GBM	SOD2 →	+1.284	+0.170	<.001	<.001	3	6
HNSC	RAB9B →	-0.468	-0.160	.002	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002227 vs FFAR2 — LSCC

Explore this scatter interactively →