Innate immune response in mucosa

Across TCGA cell cohorts, RNA activity of the Innate immune response in mucosa pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SUMO4, SOS2, and COQ6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SUMO4 grouped by Innate immune response in mucosa-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SUMO4 →	-0.166	-0.835	.003	.007	3	4
OVARY	SOS2 →	-0.674	-0.733	<.001	.007	3	3
LUNG_NSCLC_LUSC	COQ6 →	+0.869	+1.476	<.001	.003	3	3
LUNG_NSCLC_LUSC	MPST →	+0.705	+1.274	.004	.009	3	3
LUNG_NSCLC_LUAD	MMP15 →	-1.195	-0.631	<.001	.003	3	3
BLOOD_Lymphoma	POLR2E →	+0.684	+0.543	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SUMO4 by Innate immune response in mucosa activity — OVARY

Explore this box plot interactively →