Toll-like receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Toll-like receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STAT4, TNIP3, and CD274, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Toll-like receptor signaling pathway activity versus STAT4 in LSCC (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	STAT4 →	+0.762	+0.309	<.001	<.001	3	7
LSCC	TNIP3 →	+0.884	+0.296	<.001	<.001	3	7
GBM	CD274 →	+0.855	+0.171	<.001	<.001	3	7
GBM	TLR2 →	+1.083	+0.221	<.001	<.001	3	6
OV	GBP5 →	+1.254	+0.927	.001	<.001	3	6
OV	LILRB1 →	+0.859	+0.822	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002224 vs STAT4 — LSCC

Explore this scatter interactively →